Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling.

Weber, Evan W; Parker, Kevin R; Sotillo, Elena; Lynn, Rachel C; Anbunathan, Hima; Lattin, John; Good, Zinaida; Belk, Julia A; Daniel, Bence; Klysz, Dorota; Malipatlolla, Meena; Xu, Peng; Bashti, Malek; Heitzeneder, Sabine; Labanieh, Louai; Vandris, Panayiotis; Majzner, Robbie G; Qi, Yanyan; Sandor, Katalin; Chen, Ling-Chun; Prabhu, Snehit; Gentles, Andrew J; Wandless, Thomas J; Satpathy, Ansuman T; Chang, Howard Y; Mackall, Crystal L

Weber, Evan W; Parker, Kevin R; Sotillo, Elena; Lynn, Rachel C; Anbunathan, Hima; Lattin, John; Good, Zinaida; Belk, Julia A; Daniel, Bence; Klysz, Dorota; Malipatlolla, Meena; Xu, Peng; Bashti, Malek; Heitzeneder, Sabine; Labanieh, Louai; Vandris, Panayiotis; Majzner, Robbie G; Qi, Yanyan; Sandor, Katalin; Chen, Ling-Chun; Prabhu, Snehit; Gentles, Andrew J; Wandless, Thomas J; Satpathy, Ansuman T; Chang, Howard Y; Mackall, Crystal L.

Affiliation

Weber EW; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Parker KR; Department of Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA 94305, USA.
Sotillo E; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Lynn RC; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Anbunathan H; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Lattin J; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Good Z; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Belk JA; Parker Institute for Cancer Immunotherapy, San Francisco, CA 94129, USA.
Daniel B; Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA 94305, USA.
Klysz D; Department of Computer Science, Stanford University, Stanford, CA 94305, USA.
Malipatlolla M; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
Xu P; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Bashti M; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Heitzeneder S; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Labanieh L; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Vandris P; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Majzner RG; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Qi Y; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Sandor K; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Chen LC; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Prabhu S; Department of Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA 94305, USA.
Gentles AJ; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
Wandless TJ; Department of Chemical and Systems Biology, Stanford University, CA 94305, USA.
Satpathy AT; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Chang HY; Department of Biomedical Informatics Research, Stanford University School of Medicine, Stanford, CA 94305, USA.
Mackall CL; Department of Chemical and Systems Biology, Stanford University, CA 94305, USA.

Science ; 372(6537)2021 04 02.

Article de En | MEDLINE | ID: mdl-33795428

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Lymphocytes T / Immunothérapie adoptive / Épigenèse génétique / Dasatinib / Récepteurs chimériques pour l'antigène Type d'étude: Prognostic_studies Limites: Animals / Female / Humans / Male Langue: En Journal: Science Année: 2021 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique

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