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Role of increased central arterial stiffness in macro and microvascular damage in patients with coronary artery disease. / Papel del aumento de la rigidez arterial central en el daño macro y microvascular en pacientes con enfermedad coronaria.
Hidalgo-Santiago, Juan Carlos; Oneto-Otero, Jesús; Michán-Doña, Alfredo; Gomez-Fernández, Pablo.
Affiliation
  • Hidalgo-Santiago JC; Centro de Salud San Telmo, Jerez, España.
  • Oneto-Otero J; Servicio de Cardiología, Hospital Universitario de Jerez, Jerez, España.
  • Michán-Doña A; Departamento de Medicina, Hospital Universitario de Jerez, Jerez, España; Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cádiz, España.
  • Gomez-Fernández P; Unidad de Factores de Riesgo Vascular, Hospital Universitario de Jerez, Jerez, España. Electronic address: pgomezf@senefro.org.
Clin Investig Arterioscler ; 33(5): 224-234, 2021.
Article de En, Es | MEDLINE | ID: mdl-33814197
ABSTRACT

BACKGROUND:

Patients with heart disease frequently have renal dysfunction manifested by a decrease in glomerular filtration rate (GFR) and / or increase of albuminuria.

OBJECTIVES:

The objective was to study the possible role of increased aortic stiffness in the presence and extent of coronary artery disease (CAD) and kidney dysfunction in a group of patients with suspected CAD. PATIENTS AND

METHODS:

We studied forty-eight patients undergoing coronariography for suspected coronary disease (CAD). Using applanation tonometry on the radial artery and applying a transfer function, central blood pressure values were calculated. The study of aortic stiffness was done by determining the carotid-femoral pulse velocity (Pvc-f).

RESULTS:

Of the 48 patients, 11 had no significant coronary lesions, 24 showed significant lesions in 1 or 2 coronary arteries and 13 in ≥ 3 arteries. The group with a higher degree of CD had significantly higher cPP values than the group without CD. The Pvc-f increased progressively and significantly with the degree of CD. The logistic regression showed that Pvc-f independently predicted the presence of CD. The relative risk of CD increased 2.5 times for each meter of increase in Pvc-f. The GFR was negatively and significantly correlated with age and Pvc-f was associated with albuminuria.

CONCLUSIONS:

In patients with stable CD, Pvc-f, expression of aortic stiffness, is independently associated with the existence of CD and its degree of extension. The increase in arterial stiffness also participates in the decrease in GFR and in the increase in albuminuria.
Sujet(s)
Mots clés

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Maladie des artères coronaires / Rigidité vasculaire Type d'étude: Etiology_studies / Prognostic_studies Limites: Humans Langue: En / Es Journal: Clin Investig Arterioscler Année: 2021 Type de document: Article

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Maladie des artères coronaires / Rigidité vasculaire Type d'étude: Etiology_studies / Prognostic_studies Limites: Humans Langue: En / Es Journal: Clin Investig Arterioscler Année: 2021 Type de document: Article
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