20(<i>S</i>)-ginsenoside Rh2 induces caspase-dependent promyelocytic leukemia-retinoic acid receptor A degradation in NB4 cells via Akt/Bax/caspase9 and TNF-&#945;/caspase8 signaling cascades.

Zhu, Sirui; Liu, Xiaoli; Xue, Mei; Li, Yu; Cai, Danhong; Wang, Shijun; Zhang, Liang

20(S)-ginsenoside Rh2 induces caspase-dependent promyelocytic leukemia-retinoic acid receptor A degradation in NB4 cells via Akt/Bax/caspase9 and TNF-α/caspase8 signaling cascades.

Zhu, Sirui; Liu, Xiaoli; Xue, Mei; Li, Yu; Cai, Danhong; Wang, Shijun; Zhang, Liang.

Affiliation

Zhu S; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, PR China.
Liu X; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, PR China.
Xue M; College of Basic Medical Sciences, Institute of TCM-related Comorbid Depression, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, PR China.
Li Y; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, PR China.
Cai D; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, PR China.
Wang S; Shandong co-innovation center of TCM formula, College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250035, PR China.
Zhang L; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, PR China.

J Ginseng Res ; 45(2): 295-304, 2021 Mar.

Article de En | MEDLINE | ID: mdl-33841010

Mots clés

20(S)-ginsenoside Rh2; Acute promyelocytic leukemia; Apoptosis; Caspase; PML-RARA

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Langue: En Journal: J Ginseng Res Année: 2021 Type de document: Article Pays de publication: