The formation process of button ulcers in pigs experimentally infected with a subgenotype 2.1 isolate of classical swine fever virus.

Sudo, Kasumi; Yamada, Manabu; Ochiai, Mariko; Iwamoto, Shoko; Sakaki, Hajime; Kushida, Chiho; Yamashita, Maiko; Yamamoto, Atsushi; Nagasaka, Takao; Oidemizu, Mikio; Saito, Akito; Yamamoto, Kinya

Sudo, Kasumi; Yamada, Manabu; Ochiai, Mariko; Iwamoto, Shoko; Sakaki, Hajime; Kushida, Chiho; Yamashita, Maiko; Yamamoto, Atsushi; Nagasaka, Takao; Oidemizu, Mikio; Saito, Akito; Yamamoto, Kinya.

Affiliation

Sudo K; National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, 1-15-1 Tokura, Kokubunji, Tokyo 185-8511, Japan.
Yamada M; Present address: Food and Agriculture Organization of the United Nations, Viale delle Terme di Caracalla, 00153 Rome, Italy.
Ochiai M; National Institute of Animal Health, National Agriculture and Food Research Organization, 3-1-5 Kannodai, Tsukuba, Ibaraki 305-0856, Japan.
Iwamoto S; National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, 1-15-1 Tokura, Kokubunji, Tokyo 185-8511, Japan.
Sakaki H; National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, 1-15-1 Tokura, Kokubunji, Tokyo 185-8511, Japan.
Kushida C; National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, 1-15-1 Tokura, Kokubunji, Tokyo 185-8511, Japan.
Yamashita M; National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, 1-15-1 Tokura, Kokubunji, Tokyo 185-8511, Japan.
Yamamoto A; National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, 1-15-1 Tokura, Kokubunji, Tokyo 185-8511, Japan.
Nagasaka T; National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, 1-15-1 Tokura, Kokubunji, Tokyo 185-8511, Japan.
Oidemizu M; National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, 1-15-1 Tokura, Kokubunji, Tokyo 185-8511, Japan.
Saito A; National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, 1-15-1 Tokura, Kokubunji, Tokyo 185-8511, Japan.
Yamamoto K; National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, 1-15-1 Tokura, Kokubunji, Tokyo 185-8511, Japan.

J Vet Med Sci ; 83(6): 990-993, 2021 Jul 10.

Article de En | MEDLINE | ID: mdl-33867396

ABSTRACT

ABSTRACT

We evaluated the role of classical swine fever virus (CSFV) in the formation of button ulcers in the mucosa of the gastrointestinal tract. Histopathological and immunohistochemical analyses of pigs experimentally infected with a subgenotype 2.1 isolate of CSFV, which was isolated in Japan in 2019, revealed follicular necrosis in the submucosal mucosa-associated lymphoid tissue and herniation of crypts as factors that contribute to the development of button ulcers during CSFV infection. These findings indicate that CSFV induces follicular necrosis and is one of the causative agents of button ulcers in pigs.

Sujet(s)
Mots clés

button ulcer; classical swine fever virus; herniation of crypt; histopathology

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Maladies des porcs / Peste porcine classique / Virus de la peste porcine classique Limites: Animals Pays/Région comme sujet: Asia Langue: En Journal: J Vet Med Sci Sujet du journal: MEDICINA VETERINARIA Année: 2021 Type de document: Article Pays d'affiliation: Japon

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