Airway basal stem cells generate distinct subpopulations of PNECs.
Cell Rep
; 35(3): 109011, 2021 04 20.
Article
de En
| MEDLINE
| ID: mdl-33882306
ABSTRACT
Pulmonary neuroendocrine cells (PNECs) have crucial roles in airway physiology and immunity by producing bioactive amines and neuropeptides (NPs). A variety of human diseases exhibit PNEC hyperplasia. Given accumulated evidence that PNECs represent a heterogenous population of cells, we investigate how PNECs differ, whether the heterogeneity is similarly present in mouse and human cells, and whether specific disease involves discrete PNECs. Herein, we identify three distinct types of PNECs in human and mouse airways based on single and double positivity for TUBB3 and the established NP markers. We show that the three PNEC types exhibit significant differences in NP expression, homeostatic turnover, and response to injury and disease. We provide evidence that these differences parallel their distinct cell of origin from basal stem cells (BSCs) or other airway epithelial progenitors.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Cellules souches
/
Tubuline
/
Lignage cellulaire
/
Cellules épithéliales
/
Cellules neuroendocrines
Type d'étude:
Prognostic_studies
Langue:
En
Journal:
Cell Rep
Année:
2021
Type de document:
Article