Inhibition of hypoxia-inducible factor-2&#945; in renal cell carcinoma with belzutifan: a phase 1 trial and biomarker analysis.

Choueiri, Toni K; Bauer, Todd M; Papadopoulos, Kyriakos P; Plimack, Elizabeth R; Merchan, Jaime R; McDermott, David F; Michaelson, M Dror; Appleman, Leonard J; Thamake, Sanjay; Perini, Rodolfo F; Zojwalla, Naseem J; Jonasch, Eric

Inhibition of hypoxia-inducible factor-2α in renal cell carcinoma with belzutifan: a phase 1 trial and biomarker analysis.

Choueiri, Toni K; Bauer, Todd M; Papadopoulos, Kyriakos P; Plimack, Elizabeth R; Merchan, Jaime R; McDermott, David F; Michaelson, M Dror; Appleman, Leonard J; Thamake, Sanjay; Perini, Rodolfo F; Zojwalla, Naseem J; Jonasch, Eric.

Affiliation

Choueiri TK; Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA. toni_choueiri@dfci.harvard.edu.
Bauer TM; Sarah Cannon Research Institute/Tennessee Oncology, PLLC, Nashville, TN, USA.
Papadopoulos KP; South Texas Accelerated Research Therapeutics (START), San Antonio, TX, USA.
Plimack ER; Fox Chase Cancer Center, Philadelphia, PA, USA.
Merchan JR; University of Miami, Miami, FL, USA.
McDermott DF; Beth Israel Deaconess Medical Center, Boston, MA, USA.
Michaelson MD; Massachusetts General Hospital, Boston, MA, USA.
Appleman LJ; University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Thamake S; Merck & Co., Inc, Kenilworth, NJ, USA.
Perini RF; Merck & Co., Inc, Kenilworth, NJ, USA.
Zojwalla NJ; Merck & Co., Inc, Kenilworth, NJ, USA.
Jonasch E; The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ejonasch@mdanderson.org.

Nat Med ; 27(5): 802-805, 2021 05.

Article de En | MEDLINE | ID: mdl-33888901

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Néphrocarcinome / Facteurs de transcription à motif basique hélice-boucle-hélice / Tumeurs du rein / Antinéoplasiques Limites: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Langue: En Journal: Nat Med Sujet du journal: BIOLOGIA MOLECULAR / MEDICINA Année: 2021 Type de document: Article Pays d'affiliation: États-Unis d'Amérique

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