Prognostic significance of Tp-e interval and Tp-e/QTc ratio in patients with COVID-19.
Eur Rev Med Pharmacol Sci
; 25(8): 3272-3278, 2021 04.
Article
de En
| MEDLINE
| ID: mdl-33928614
ABSTRACT
OBJECTIVE:
Ventricular arrhythmias were the most frequent manifestations in patients with COVID-19. Both the natural course of the disease and the treatment drugs used have effects on ventricular repolarization. The objective of this study was to evaluate the effects of repolarization parameters obtained from surface electrocardiography (ECG) on prognosis. PATIENTS ANDMETHODS:
Participants were 205 consecutive patients hospitalized with COVID-19 diagnosis. The 12-lead surface ECG was obtained from each patient on admission. The ECG results were evaluated against the patients' clinical characteristics and outcomes by experienced cardiology specialists.RESULTS:
The mean age was higher in the non-survivor group compared to the survivor group (57.4 ± 15.7 vs. 65.6 ± 16.6; p = 0.001). The demographical characteristics were similar between the survivor and non-survivor groups. Multivariate analyses demonstrated that age (OR 1.041; p = 0.009), D-dimer (OR 1.002; p = 0.031), high-sensitivity troponin I (hs-TnI) (OR 1.010; p = 0.041), pneumonia on computed tomography (CT) (OR 4.985; p < 0.001), the peak-to-end interval of the T wave (Tp-e) (OR 3.421; p < 0.001), and Tp-e/QTc ratio (OR 1.978; p = 0.013) were statistically significant independent predictors in terms of determining mortality.CONCLUSIONS:
Prolonged Tp-e interval and increased Tp-e/QTc ratio on admission are decent predictors and linked with mortality. ECG is a practical study to evaluate prognosis and potential arrhythmias, as well as initiating suitable treatment.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Troubles du rythme cardiaque
/
COVID-19
Type d'étude:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Eur Rev Med Pharmacol Sci
Sujet du journal:
FARMACOLOGIA
/
TOXICOLOGIA
Année:
2021
Type de document:
Article
Pays d'affiliation:
Turquie