Most Japanese individuals are genetically predisposed to recognize an immunogenic protein fragment shared between COVID-19 and common cold coronaviruses.
F1000Res
; 10: 196, 2021.
Article
de En
| MEDLINE
| ID: mdl-34026045
ABSTRACT
In the spring of 2020, we and others hypothesized that T cells in COVID-19 patients may recognize identical protein fragments shared between the coronaviruses of the common cold and COVID-19 and thereby confer cross-virus immune memory. Here, we look at this issue by screening studies that, since that time, have experimentally addressed COVID-19 associated T cell specificities. Currently, the identical T cell epitope shared between COVID-19 and common cold coronaviruses most convincingly identified as immunogenic is the CD8 + T cell epitope VYIGDPAQL if presented by the MHC class I allele HLA-A*2402. The HLA-A*2402 allele is found in the majority of Japanese individuals and several indigenous populations in Asia, Oceania, and the Americas. In combination with histories of common cold infections, HLA-A*2402 may affect their protection from COVID-19.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Rhume banal
/
COVID-19
Type d'étude:
Prognostic_studies
Limites:
Humans
Pays/Région comme sujet:
Asia
Langue:
En
Journal:
F1000Res
Année:
2021
Type de document:
Article
Pays d'affiliation:
Japon