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Association of sarcopenia with a higher risk of infection in patients with type 2 diabetes.
Zhang, Yongze; Weng, Suiyan; Huang, Lingning; Shen, Ximei; Zhao, Fengying; Yan, Sunjie.
Affiliation
  • Zhang Y; Department of Endocrinology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
  • Weng S; Fujian Province Clinical Research Center for Metabolic Diseases, Fuzhou, Fujian, China.
  • Huang L; Diabetes Research Institute of Fujian Province, Fuzhou, Fujian, China.
  • Shen X; Metabolic Diseases Research Institute, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
  • Zhao F; Department of Endocrinology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
  • Yan S; Diabetes Research Institute of Fujian Province, Fuzhou, Fujian, China.
Diabetes Metab Res Rev ; 38(1): e3478, 2022 01.
Article de En | MEDLINE | ID: mdl-34041847
AIMS: This study aimed to determine whether patients with type 2 diabetes and sarcopenia had a higher risk of infection. STUDY DESIGNS: A cross-sectional study and a follow-up study were performed. METHOD: A total of 2562 patients were enrolled and assessed for body composition and infection status. They were classified into four groups according to body fat (BF) and muscle mass index (ASMI): obese, sarcopenic, sarcopenic obese, and normal. Among these, 275 patients were followed for a median follow-up period of 1.84 years to evaluate the relationship of changes in skeletal muscle with infection status. RESULTS: The sarcopenic and sarcopenic obese groups showed a higher risk of infection, an increase by 49.6% (OR = 1.496, 95% CI 1.102-2.031) and 42.4% (OR = 1.424, 95% CI 1.031-1.967) compared with the normal group, and also had a higher risk of respiratory infection, an increase by 56.0% (OR = 1.560, 95% CI 1.084-2.246) and 57.4% (OR = 1.574, 95% CI 1.080-2.293), respectively. Patients with the increased ASMI (OR = 0.079, 95% CI 0.021-0.298) represented a lower risk of infection than those with the decreased ASMI. Even a minor change (OR = 0.125, 95% CI 0.041-0.378) against age was beneficial to lowering the risk of infection. However, no association was found in the changes of body mass index and BF with infection status. CONCLUSIONS: Sarcopenia, especially in patients with diabetes who are also obese, increases the risk of infection. Maintaining or improving muscle mass is expected to reduce infections.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Diabète de type 2 / Sarcopénie Type d'étude: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limites: Humans Langue: En Journal: Diabetes Metab Res Rev Sujet du journal: ENDOCRINOLOGIA / METABOLISMO Année: 2022 Type de document: Article Pays d'affiliation: Chine Pays de publication: Royaume-Uni

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Diabète de type 2 / Sarcopénie Type d'étude: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limites: Humans Langue: En Journal: Diabetes Metab Res Rev Sujet du journal: ENDOCRINOLOGIA / METABOLISMO Année: 2022 Type de document: Article Pays d'affiliation: Chine Pays de publication: Royaume-Uni