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Management of Organophosphorus Poisoning: Standard Treatment and Beyond.
Aman, Sakib; Paul, Shrebash; Chowdhury, Fazle Rabbi.
Affiliation
  • Aman S; Department of Medicine, Dhaka Medical College Hospital, Secretariat Road, Dhaka 1000, Bangladesh.
  • Paul S; Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka 1000, Bangladesh.
  • Chowdhury FR; Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka 1000, Bangladesh. Electronic address: masterfazlerabbi@gmail.com.
Crit Care Clin ; 37(3): 673-686, 2021 Jul.
Article de En | MEDLINE | ID: mdl-34053713
Organophosphorus (OP) compounds remain a leading cause of self-poisoning and mortality, especially in South East Asia, China, and Africa. Organophosphorus causes an acute cholinergic syndrome by inhibiting acetylcholinesterase. Atropine remains the mainstay of treatment, but recently some promising therapies are in the pipeline. Oximes are used widely in the management of organophosphorus poisoning, however clinical efficacy remains to be established. Magnesium sulfate, calcium channel blockers (nimodipine), plasma alkalinizing agents, ß-2 agonists, nicotinic receptor antagonists, clonidine, and lipid emulsions are promising treatment alternatives. However, large phase III trials are required to establish their efficacy.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Intoxication / Intoxication aux organophosphates Limites: Humans Langue: En Journal: Crit Care Clin Sujet du journal: TERAPIA INTENSIVA Année: 2021 Type de document: Article Pays d'affiliation: Bangladesh Pays de publication: États-Unis d'Amérique

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Intoxication / Intoxication aux organophosphates Limites: Humans Langue: En Journal: Crit Care Clin Sujet du journal: TERAPIA INTENSIVA Année: 2021 Type de document: Article Pays d'affiliation: Bangladesh Pays de publication: États-Unis d'Amérique