The Discovery of Naringenin as Endolysosomal Two-Pore Channel Inhibitor and Its Emerging Role in SARS-CoV-2 Infection.
Cells
; 10(5)2021 05 07.
Article
de En
| MEDLINE
| ID: mdl-34067054
ABSTRACT
The flavonoid naringenin (Nar), present in citrus fruits and tomatoes, has been identified as a blocker of an emerging class of human intracellular channels, namely the two-pore channel (TPC) family, whose role has been established in several diseases. Indeed, Nar was shown to be effective against neoangiogenesis, a process essential for solid tumor progression, by specifically impairing TPC activity. The goal of the present review is to illustrate the rationale that links TPC channels to the mechanism of coronavirus infection, and how their inhibition by Nar could be an efficient pharmacological strategy to fight the current pandemic plague COVID-19.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Inhibiteurs des canaux calciques
/
Canaux calciques
/
Flavanones
/
Traitements médicamenteux de la COVID-19
/
Tumeurs
Limites:
Humans
Langue:
En
Journal:
Cells
Année:
2021
Type de document:
Article
Pays d'affiliation:
Italie