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NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells.
Geles, Kenneth G; Gao, Yijie; Giannakou, Andreas; Sridharan, Latha; Yamin, Ting-Ting; Zhang, Jing; Karim, Riyez; Bard, Joel; Piche-Nicholas, Nicole; Charati, Manoj; Maderna, Andreas; Lucas, Judy; Golas, Jonathon; Guffroy, Magali; Pirie-Shepherd, Steven; Roy, Marc; Qian, Jessie; Franks, Tania; Zhong, Wenyan; O'Donnell, Christopher J; Tchistiakova, Lioudmila; Gerber, Hans-Peter; Sapra, Puja.
Affiliation
  • Geles KG; Pfizer Worldwide Research and Development, Oncology Research and Development, Pearl River, NY, USA.
  • Gao Y; BioMedicine Design, Cambridge, MA, USA.
  • Giannakou A; Pfizer Worldwide Research and Development, Oncology Research and Development, Pearl River, NY, USA.
  • Sridharan L; Pfizer Worldwide Research and Development, Oncology Research and Development, Pearl River, NY, USA.
  • Yamin TT; Pfizer Worldwide Research and Development, Oncology Research and Development, Pearl River, NY, USA.
  • Zhang J; BioMedicine Design, Cambridge, MA, USA.
  • Karim R; BioMedicine Design, Cambridge, MA, USA.
  • Bard J; BioMedicine Design, Cambridge, MA, USA.
  • Piche-Nicholas N; BioMedicine Design, Cambridge, MA, USA.
  • Charati M; Pfizer Worldwide Research and Development, Oncology Research and Development, Pearl River, NY, USA.
  • Maderna A; Medicinal Chemistry, Groton, CT, USA.
  • Lucas J; Pfizer Worldwide Research and Development, Oncology Research and Development, Pearl River, NY, USA.
  • Golas J; Pfizer Worldwide Research and Development, Oncology Research and Development, Pearl River, NY, USA.
  • Guffroy M; Drug Safety Research and Development, Pearl River, NY, USA.
  • Pirie-Shepherd S; Oncology Research and Development, San Diego, CA, USA.
  • Roy M; Drug Safety Research and Development, Groton, CT, USA.
  • Qian J; Drug Safety Research and Development, Groton, CT, USA.
  • Franks T; Drug Safety Research and Development, Groton, CT, USA.
  • Zhong W; Pfizer Worldwide Research and Development, Oncology Research and Development, Pearl River, NY, USA.
  • O'Donnell CJ; Medicinal Chemistry, Groton, CT, USA.
  • Tchistiakova L; BioMedicine Design, Cambridge, MA, USA.
  • Gerber HP; Pfizer Worldwide Research and Development, Oncology Research and Development, Pearl River, NY, USA.
  • Sapra P; Pfizer Worldwide Research and Development, Oncology Research and Development, Pearl River, NY, USA.
Cell Rep Med ; 2(5): 100279, 2021 05 18.
Article de En | MEDLINE | ID: mdl-34095881
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Apoptose / Immunoconjugués / Récepteur Notch3 / Antinéoplasiques Limites: Humans Langue: En Journal: Cell Rep Med Année: 2021 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Apoptose / Immunoconjugués / Récepteur Notch3 / Antinéoplasiques Limites: Humans Langue: En Journal: Cell Rep Med Année: 2021 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique