Association between obesity and risk of fracture, bone mineral density and bone quality in adults: A systematic review and meta-analysis.
PLoS One
; 16(6): e0252487, 2021.
Article
de En
| MEDLINE
| ID: mdl-34101735
ABSTRACT
BACKGROUND:
The association between obesity and fracture risk may be skeletal site- and sex-specific but results among studies are inconsistent. Whilst several studies reported higher bone mineral density (BMD) in patients with obesity, altered bone quality could be a major determinant of bone fragility in this population.OBJECTIVES:
This systematic review and meta-analysis aimed to compare, in men, premenopausal women and postmenopausal women with obesity vs. individuals without obesity 1) the incidence of fractures overall and by site; 2) BMD; and 3) bone quality parameters (circulating bone turnover markers and bone microarchitecture and strength by advanced imaging techniques). DATA SOURCES PubMed (MEDLINE), EMBASE, Cochrane Library and Web of Science were searched from inception of databases until the 13th of January 2021. DATASYNTHESIS:
Each outcome was stratified by sex and menopausal status in women. The meta-analysis was performed using a random-effect model with inverse-variance method. The risks of hip and wrist fracture were reduced by 25% (n = 8 RR = 0.75, 95% CI 0.62, 0.91, P = 0.003, I2 = 95%) and 15% (n = 2 studies RR = 0.85, 95% CI 0.81, 0.88), respectively, while ankle fracture risk was increased by 60% (n = 2 studies RR = 1.60, 95% CI 1.52, 1.68) in postmenopausal women with obesity compared with those without obesity. In men with obesity, hip fracture risk was decreased by 41% (n = 5 studies RR = 0.59, 95% CI 0.44, 0.79). Obesity was associated with increased BMD, better bone microarchitecture and strength, and generally lower or unchanged circulating bone resorption, formation and osteocyte markers. However, heterogeneity among studies was high for most outcomes, and overall quality of evidence was very low to low for all outcomes.CONCLUSIONS:
This meta-analysis highlights areas for future research including the need for site-specific fracture studies, especially in men and premenopausal women, and studies comparing bone microarchitecture between individuals with and without obesity. SYSTEMATIC REVIEW REGISTRATION NUMBER CRD42020159189.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Ostéoporose post-ménopausique
/
Obésité
Type d'étude:
Clinical_trials
/
Etiology_studies
/
Risk_factors_studies
/
Systematic_reviews
Limites:
Female
/
Humans
/
Male
Langue:
En
Journal:
PLoS One
Sujet du journal:
CIENCIA
/
MEDICINA
Année:
2021
Type de document:
Article
Pays d'affiliation:
Canada