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Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study.
Kaitu'u-Lino, Tu'uhevaha J; Tong, Stephen; Walker, Susan P; MacDonald, Teresa M; Cannon, Ping; Nguyen, Tuong-Vi; Sadananthan, Suresh Anand; Tint, Mya-Thway; Ong, Yi Ying; Ling, Loy See; Gluckman, Peter D; Chong, Yap-Seng; Godfrey, Keith M; Chan, Shiao-Yng; Tan, Kok Hian; Lee, Yung Seng; Michael, Navin; Eriksson, Johan G; Wlodek, Mary E.
Affiliation
  • Kaitu'u-Lino TJ; Translational Obstetrics Group, Mercy Hospital for Women, 163 Studley Road, Heidelberg, 3084, Victoria, Australia; The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Victoria, Australia; Mercy Perinatal, Mercy Hospital for Women, Victoria, Australia. Ele
  • Tong S; Translational Obstetrics Group, Mercy Hospital for Women, 163 Studley Road, Heidelberg, 3084, Victoria, Australia; The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Victoria, Australia; Mercy Perinatal, Mercy Hospital for Women, Victoria, Australia.
  • Walker SP; The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Victoria, Australia; Mercy Perinatal, Mercy Hospital for Women, Victoria, Australia.
  • MacDonald TM; The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Victoria, Australia; Mercy Perinatal, Mercy Hospital for Women, Victoria, Australia.
  • Cannon P; Translational Obstetrics Group, Mercy Hospital for Women, 163 Studley Road, Heidelberg, 3084, Victoria, Australia; The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Victoria, Australia.
  • Nguyen TV; Translational Obstetrics Group, Mercy Hospital for Women, 163 Studley Road, Heidelberg, 3084, Victoria, Australia; The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Victoria, Australia.
  • Sadananthan SA; Singapore Institute of Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore.
  • Tint MT; Singapore Institute of Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore; Department of Obstetrics and Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Ong YY; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Ling LS; Singapore Institute of Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore; Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, 229899; Duke-NUS Medical School, Singapore, 169857.
  • Gluckman PD; Singapore Institute of Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore; Liggins Institute, University of Auckland, Auckland, New Zealand.
  • Chong YS; Singapore Institute of Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore; Department of Obstetrics and Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Godfrey KM; MRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, UK.
  • Chan SY; Singapore Institute of Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore; Department of Obstetrics and Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Tan KH; Department of Maternal FetaL Medicine KK Women's and Children's Hospital Singapore, Singapore.
  • Lee YS; Singapore Institute of Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Michael N; Singapore Institute of Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore.
  • Eriksson JG; Singapore Institute of Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore; Department of Obstetrics and Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Genera
  • Wlodek ME; The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Victoria, Australia; Singapore Institute of Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore; Department of Obstetrics and Gynaecology and Human Potential Translational
Placenta ; 110: 24-28, 2021 07.
Article de En | MEDLINE | ID: mdl-34102451
ABSTRACT
Fetal growth restriction arising from placental insufficiency is a leading cause of stillbirth. We recently identified low maternal circulating SPINT1 concentrations as a novel biomarker of poor fetal growth. Here we measured SPINT1 in a prospective cohort in Singapore. Circulating SPINT1 concentrations were significantly lower among 141 pregnant women destined to deliver small-for-gestational age infants (birthweight <10th centile), compared to 772 controls (p < 0.01) at as early as 26 weeks' gestation. There were no correlations between infant body composition and circulating SPINT1 concentrations at 26 weeks. This provides validation that low maternal SPINT1 concentration is associated with poor fetal growth.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Insuffisance placentaire / Protéines sécrétoires inhibitrices de protéinases / Retard de croissance intra-utérin Type d'étude: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limites: Adult / Female / Humans / Newborn / Pregnancy Pays/Région comme sujet: Asia Langue: En Journal: Placenta Année: 2021 Type de document: Article
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Insuffisance placentaire / Protéines sécrétoires inhibitrices de protéinases / Retard de croissance intra-utérin Type d'étude: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limites: Adult / Female / Humans / Newborn / Pregnancy Pays/Région comme sujet: Asia Langue: En Journal: Placenta Année: 2021 Type de document: Article