REV7 directs DNA repair pathway choice.
Trends Cell Biol
; 31(12): 965-978, 2021 12.
Article
de En
| MEDLINE
| ID: mdl-34147298
ABSTRACT
REV7 is a small multifunctional protein that participates in multiple DNA repair pathways, most notably translesion DNA synthesis and double-strand break (DSB) repair. While the role of REV7 in translesion synthesis has been known for several decades, its function in DSB repair is a recent discovery. Investigations into the DSB repair function of REV7 have led to the discovery of a new DNA repair complex known as Shieldin. Recent studies have also highlighted the importance of REV7's HORMA domain, an ancient structural motif, in REV7 function and have identified the HORMA regulators, TRIP13 and p31, as novel DNA repair factors. In this review, we discuss these recent findings and their implications for repair pathway choice, at both DSBs and replication forks. We suggest that REV7, in particular the activation state of its HORMA domain, can act as a critical determinant of mutagenic versus error-free repair in multiple contexts.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Protéines du cycle cellulaire
/
Réparation de l'ADN
/
Protéines Mad2
Type d'étude:
Prognostic_studies
Langue:
En
Journal:
Trends Cell Biol
Année:
2021
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique