EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart.

Hambarde, Shashank; Tsai, Chi-Lin; Pandita, Raj K; Bacolla, Albino; Maitra, Anirban; Charaka, Vijay; Hunt, Clayton R; Kumar, Rakesh; Limbo, Oliver; Le Meur, Remy; Chazin, Walter J; Tsutakawa, Susan E; Russell, Paul; Schlacher, Katharina; Pandita, Tej K; Tainer, John A

Hambarde, Shashank; Tsai, Chi-Lin; Pandita, Raj K; Bacolla, Albino; Maitra, Anirban; Charaka, Vijay; Hunt, Clayton R; Kumar, Rakesh; Limbo, Oliver; Le Meur, Remy; Chazin, Walter J; Tsutakawa, Susan E; Russell, Paul; Schlacher, Katharina; Pandita, Tej K; Tainer, John A.

Affiliation

Hambarde S; Department of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX 77030, USA; Department of Neurosurgery, The Houston Methodist Research Institute, Houston, TX 77030, USA.
Tsai CL; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Pandita RK; Department of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX 77030, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Bacolla A; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Maitra A; Sheikh Ahmed Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Charaka V; Department of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX 77030, USA.
Hunt CR; Department of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX 77030, USA.
Kumar R; School of Biotechnology, Shri Mata Vashino Devi University, Katra, Jammu and Kashmir, 182320, India.
Limbo O; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Le Meur R; Departments of Biochemistry and Chemistry and Center for Structural Biology, Vanderbilt University, Nashville, TN 37240, USA.
Chazin WJ; Departments of Biochemistry and Chemistry and Center for Structural Biology, Vanderbilt University, Nashville, TN 37240, USA.
Tsutakawa SE; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Russell P; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Schlacher K; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Pandita TK; Department of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX 77030, USA; Department of Neurosurgery, The Houston Methodist Research Institute, Houston, TX 77030, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. Electron
Tainer JA; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; Department of Cancer Biology, The University of Texas MD Anderson

Mol Cell ; 81(14): 2989-3006.e9, 2021 07 15.

Article de En | MEDLINE | ID: mdl-34197737

Sujet(s)
Mots clés

ATR phosphorylation; Bloom; Fanconi anemia; SCE; exonuclease; fork restart; genetic instability; interstrand crosslink repair; replication stress; sister chromatid exchange; tumor proliferation

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: ADN / Instabilité du génome / Réplication de l'ADN / Exonucleases / RecQ helicases / Protéines mutées dans l'ataxie-télangiectasie Limites: Humans Langue: En Journal: Mol Cell Sujet du journal: BIOLOGIA MOLECULAR Année: 2021 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique

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