Controlling BMP growth factor bioavailability: The extracellular matrix as multi skilled platform.
Cell Signal
; 85: 110071, 2021 09.
Article
de En
| MEDLINE
| ID: mdl-34217834
ABSTRACT
Bone morphogenetic proteins (BMPs) belong to the TGF-ß superfamily of signaling ligands which comprise a family of pluripotent cytokines regulating a multitude of cellular events. Although BMPs were originally discovered as potent factors extractable from bone matrix that are capable to induce ectopic bone formation in soft tissues, their mode of action has been mostly studied as soluble ligands in absence of the physiologically relevant cellular microenvironment. This micro milieu is defined by supramolecular networks of extracellular matrix (ECM) proteins that specifically target BMP ligands, present them to their cellular receptors, and allow their controlled release. Here we focus on functional interactions and mechanisms that were described to control BMP bioavailability in a spatio-temporal manner within the respective tissue context. Structural disturbance of the ECM architecture due to mutations in ECM proteins leads to dysregulated BMP signaling as underlying cause for connective tissue disease pathways. We will provide an overview about current mechanistic concepts of how aberrant BMP signaling drives connective tissue destruction in inherited and chronic diseases.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Protéines morphogénétiques osseuses
/
Matrice extracellulaire
Langue:
En
Journal:
Cell Signal
Année:
2021
Type de document:
Article
Pays d'affiliation:
Allemagne