Human variability in polymorphic CYP2D6 metabolism: Implications for the risk assessment of chemicals in food and emerging designer drugs.

Darney, K; Lautz, L S; Béchaux, C; Wiecek, W; Testai, E; Amzal, B; Dorne, J L C M

Darney, K; Lautz, L S; Béchaux, C; Wiecek, W; Testai, E; Amzal, B; Dorne, J L C M.

Affiliation

Darney K; French Agency for Food, Environmental and Occupational Health & Safety (ANSES), 14 rue Pierre et Marie Curie, 94701 Maisons-Alfort, France.
Lautz LS; French Agency for Food, Environmental and Occupational Health & Safety (ANSES), 14 rue Pierre et Marie Curie, 94701 Maisons-Alfort, France.
Béchaux C; French Agency for Food, Environmental and Occupational Health & Safety (ANSES), 14 rue Pierre et Marie Curie, 94701 Maisons-Alfort, France.
Wiecek W; Certara UK Ltd, Audrey House, 5th Floor, 16-20 Ely Place, London EC1N 6SN, United Kingdom.
Testai E; Istituto Superior di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
Amzal B; Quinten Health, 75017 Paris, France.
Dorne JLCM; European Food Safety Authority, Via Carlo Magno,1A, 43126 Parma, Italy. Electronic address: jean-lou.dorne@efsa.europa.eu.

Environ Int ; 156: 106760, 2021 11.

Article de En | MEDLINE | ID: mdl-34256299

Sujet(s)
Mots clés

Bayesian inference; CYP2D6; Human variability; Meta-analysis; Pharmacokinetics; Risk assessment; Uncertainty factors

Texte intégral

Ajouter à My VHL

Imprimer

XML

PubMed Links

Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Drogues fabriquées clandestinement / Cytochrome P-450 CYP2D6 Type d'étude: Etiology_studies / Prognostic_studies / Risk_factors_studies Limites: Humans Langue: En Journal: Environ Int Année: 2021 Type de document: Article Pays d'affiliation: France

Texte intégral

Ajouter à My VHL

Imprimer

XML

PubMed Links

Recherche sur Google