Clinical and Radiological Phenotypes and Endotypes.
Semin Respir Crit Care Med
; 42(4): 549-555, 2021 08.
Article
de En
| MEDLINE
| ID: mdl-34261179
ABSTRACT
Bronchiectasis is a heterogenous disease with multiple etiologies and associated comorbidities. As bronchiectasis is a complex disease, it is unsound to think of it as a single disease particularly when the differing etiologies are likely to be driving bronchiectasis through initial divergent molecular pathways, known as endotypes, that phenotypically present as the same disease due to protracted airway inflammation, but revealing potential differing underlying mechanisms that may have disparity of drug responses. Improved understanding of the cellular immune, inflammatory, and microbiological milieu associated with clinical and radiological features of bronchiectasis has resulted in the recognition of important endotypes and phenotypes that will allow for personalized treatments to improve quality of life and outcomes of patients with bronchiectasis. Here we discuss clinical and radiological phenotypes, as well as emerging molecular endotypes that are possible treatable traits in bronchiectasis.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Qualité de vie
/
Dilatation des bronches
Type d'étude:
Diagnostic_studies
Aspects:
Patient_preference
Limites:
Humans
Langue:
En
Journal:
Semin Respir Crit Care Med
Sujet du journal:
TERAPIA INTENSIVA
Année:
2021
Type de document:
Article
Pays d'affiliation:
Royaume-Uni