Endometriosis-associated cancer.
Climacteric
; 24(6): 587-592, 2021 12.
Article
de En
| MEDLINE
| ID: mdl-34269136
ABSTRACT
Endometriosis will affect about 10% of the female population and not only can it significantly impact adversely on quality of life and result in infertility, but data are accumulating that malignant transformation is an important consideration. Endometriosis can be histologically typical or atypical, ovarian, superficial peritoneal or deep infiltrating. The precursor for malignant transformation appears to be the ovarian atypical endometriosis component. Ovarian cancer is the most important associated cancer, primarily endometrioid and clear cell cancer. These are the only subtypes wherein a direct clonal relationship between endometriosis, as a direct precursor, and cancer has been made. There is no substantive evidence to support an altered association of borderline cancers of the ovary, serous ovarian cancers and breast, endometrial or cervical cancers. This review provides an overview of the prevailing data pertaining to the molecular and genetic aberrations that accompany the transformation of atypical endometriosis to malignancy and the accumulated epidemiologic evidence which supports the association.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs de l'ovaire
/
Endométriose
Type d'étude:
Risk_factors_studies
Aspects:
Patient_preference
Limites:
Female
/
Humans
Langue:
En
Journal:
Climacteric
Sujet du journal:
GINECOLOGIA
Année:
2021
Type de document:
Article
Pays d'affiliation:
République d'Afrique du Sud