A Cyanine-Mediated Self-Assembly System for the Construction of a Two-in-One Nanodrug.
Angew Chem Int Ed Engl
; 60(39): 21226-21230, 2021 09 20.
Article
de En
| MEDLINE
| ID: mdl-34296814
ABSTRACT
The combination of gene therapy and chemotherapy provides a We developed a simple and versatile approach to prepare a series of two-in-one nanodrugs through direct self-assembly of cyanine-labeled single-stranded DNA (Cys-DNA) and different types of drug molecules. Molecular dynamics simulation showed that the Cys introduced into the DNA could enhance the noncovalent interaction between Cys-DNA and drug molecules. More drug molecules were incorporated into Cys-DNA, tending to spontaneously form hybrid Cys-DNA/drug nanosphere. Such nanospheres serve as both carriers and cargoes, excluding the extra use of nontherapeutic excipients and showing ultrahigh drug loading capacity. Following this approach, an antisense oligonucleotides/doxorubicin nanodrug model was constructed, demonstrating the significant synergistic anti-tumor therapeutic effect. As a proof of the concept, our study establishes a simple and reproducible two-in-one nucleic acid-based drug formulation.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
ADN
/
Carbocyanines
/
Doxorubicine
/
Oligonucléotides antisens
/
Nanoparticules
/
Antibiotiques antinéoplasiques
Limites:
Humans
Langue:
En
Journal:
Angew Chem Int Ed Engl
Année:
2021
Type de document:
Article