The Increase of Antileukemic Efficiency of Doxorubicin and Other Cytostatics Combined with Platinum(IV)-Nitroxyl Complex ÐÐ¡118.

Goncharova, S A; Raevskaya, T A; Klimanova, E N; Sen', V D

The Increase of Antileukemic Efficiency of Doxorubicin and Other Cytostatics Combined with Platinum(IV)-Nitroxyl Complex ÐÐ¡118.

Goncharova, S A; Raevskaya, T A; Klimanova, E N; Sen', V D.

Affiliation

Goncharova SA; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow region, Russia. sago@icp.ac.ru.
Raevskaya TA; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow region, Russia.
Klimanova EN; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow region, Russia.
Sen' VD; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow region, Russia.

Bull Exp Biol Med ; 171(3): 342-346, 2021 Jul.

Article de En | MEDLINE | ID: mdl-34297288

ABSTRACT

ABSTRACT

Combined treatment of murine leukemia P388 with doxorubicin and platinum(IV)-nitroxyl complex ÐÐ¡118 administered in low doses improved efficiency of treatment (cure of 83% of animals) without increasing toxicity.

Sujet(s)
Mots clés

antitumor cytostatics; combined therapy; monotherapy; platinum(IV)-nitroxyl complex ÐÐ¡118; toxicity

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Composés organiques du platine / Leucémie P388 / Protocoles de polychimiothérapie antinéoplasique / Doxorubicine / Cytostatiques Limites: Animals Langue: En Journal: Bull Exp Biol Med Année: 2021 Type de document: Article Pays d'affiliation: Russie

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