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Influence of dietary habits on depression among patients with rheumatoid arthritis: A cross-sectional study using KURAMA cohort database.
Minamino, Hiroto; Katsushima, Masao; Hashimoto, Motomu; Fujita, Yoshihito; Torii, Mie; Ikeda, Kaori; Isomura, Nozomi; Oguri, Yasuo; Yamamoto, Wataru; Watanabe, Ryu; Murakami, Kosaku; Murata, Koichi; Nishitani, Kohei; Tanaka, Masao; Ito, Hiromu; Uda, Miyabi; Nin, Kazuko; Arai, Hidenori; Matsuda, Shuichi; Morinobu, Akio; Inagaki, Nobuya.
Affiliation
  • Minamino H; Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Katsushima M; Japan Society for the Promotion of Science, Tokyo, Japan.
  • Hashimoto M; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Fujita Y; Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Torii M; Department of Clinical Immunology, Graduate School of Medicine, Osaka City University, Osaka, Japan.
  • Ikeda K; Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Isomura N; Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Oguri Y; Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Yamamoto W; Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Watanabe R; Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Murakami K; Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
  • Murata K; Department of Health Information Management, Kurashiki Sweet Hospital, Okayama, Japan.
  • Nishitani K; Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Tanaka M; Department of Clinical Immunology, Graduate School of Medicine, Osaka City University, Osaka, Japan.
  • Ito H; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Uda M; Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Nin K; Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Arai H; Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Matsuda S; Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Morinobu A; Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Inagaki N; Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
PLoS One ; 16(8): e0255526, 2021.
Article de En | MEDLINE | ID: mdl-34351967
ABSTRACT

OBJECTIVE:

Although mental disorder is one of the most common comorbidities of rheumatoid arthritis (RA) and is known as a critical influence on RA remission rates, there is little knowledge regarding a possible therapeutic strategy for depression or anxiety in a RA population. Most recently, clinical evidence of dietary improvement for depression has emerged in a general population, but the relationship between dietary habits and mental disorder has not been investigated in RA. The purpose of this study is to elucidate clinical associations between mental disorder (depression/anxiety), dietary habits and disease activity/physical function in patients with RA.

METHODS:

A cross-sectional study was performed with 267 female outpatients from the KURAMA database. Using the Hospital Anxiety and Depression Scale (HADS), we classified the participants into three groups by depression state, and their characteristics were compared. Using the 20-items on the self-reported food frequency questionnaire, we investigated the relationship between dietary habits and depression or anxiety, adopting a trend test and a multivariate standardized linear regression analysis for the HADS score of depression or that of anxiety as a dependent variable.

RESULTS:

According to the classified stage of depression, current disease activity (DAS28-CRP 28-Joint RA Disease Activity Score-C-reactive protein) and the health assessment questionnaire disability Index (HAQ-DI) were significantly increased. Trend analyses revealed that the depression score was inversely associated with the consumption of three food (fish, vegetables and fruit) out of twenty as was the anxiety score with only fish intake. Furthermore, multiple linear regression analysis revealed that the depression score was negatively associated with frequent fish intake (≥ 3 times per week) (Estimate -0.53, p = 0.033), HAQ-DI score within normal range (Estimate -0.88, p ≤ 0.001) and MTX use (Estimate -0.60, p ≤ 0.023). For the anxiety score, multivariate analysis showed similar but not significant associations with variables except for HAQ-DI score.

CONCLUSIONS:

In a RA population, both depression and anxiety had a significant and negative association with HAQ-DI score, and depression rather than anxiety had negative association with frequent fish intake. Modification of dietary habits such as increased fish consumption may have a beneficial effect on the depression state in RA patients.
Sujet(s)

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Anxiété / Polyarthrite rhumatoïde / Qualité de vie / Indice de gravité de la maladie / Dépression / Comportement alimentaire Type d'étude: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies Aspects: Patient_preference Limites: Female / Humans / Middle aged Langue: En Journal: PLoS One Sujet du journal: CIENCIA / MEDICINA Année: 2021 Type de document: Article Pays d'affiliation: Japon

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Anxiété / Polyarthrite rhumatoïde / Qualité de vie / Indice de gravité de la maladie / Dépression / Comportement alimentaire Type d'étude: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies Aspects: Patient_preference Limites: Female / Humans / Middle aged Langue: En Journal: PLoS One Sujet du journal: CIENCIA / MEDICINA Année: 2021 Type de document: Article Pays d'affiliation: Japon
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