MMP2 Modulates Inflammatory Response during Axonal Regeneration in the Murine Visual System.
Cells
; 10(7)2021 07 02.
Article
de En
| MEDLINE
| ID: mdl-34359839
ABSTRACT
Neuroinflammation has been put forward as a mechanism triggering axonal regrowth in the mammalian central nervous system (CNS), yet little is known about the underlying cellular and molecular players connecting these two processes. In this study, we provide evidence that MMP2 is an essential factor linking inflammation to axonal regeneration by using an in vivo mouse model of inflammation-induced axonal regeneration in the optic nerve. We show that infiltrating myeloid cells abundantly express MMP2 and that MMP2 deficiency results in reduced long-distance axonal regeneration. However, this phenotype can be rescued by restoring MMP2 expression in myeloid cells via a heterologous bone marrow transplantation. Furthermore, while MMP2 deficiency does not affect the number of infiltrating myeloid cells, it does determine the coordinated expression of pro- and anti-inflammatory molecules. Altogether, in addition to its role in axonal regeneration via resolution of the glial scar, here, we reveal a new mechanism via which MMP2 facilitates axonal regeneration, namely orchestrating the expression of pro- and anti-inflammatory molecules by infiltrating innate immune cells.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Nerf optique
/
Axones
/
Transplantation de moelle osseuse
/
Lésions traumatiques du nerf optique
/
Matrix metalloproteinase 2
/
Régénération nerveuse
Type d'étude:
Prognostic_studies
Limites:
Animals
Langue:
En
Journal:
Cells
Année:
2021
Type de document:
Article
Pays d'affiliation:
Belgique