UDP-glucuronosyltransferase 1A4-mediated N2-glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised-livers.

Uehara, Shotaro; Higuchi, Yuichiro; Yoneda, Nao; Yamazaki, Hiroshi; Suemizu, Hiroshi

Uehara, Shotaro; Higuchi, Yuichiro; Yoneda, Nao; Yamazaki, Hiroshi; Suemizu, Hiroshi.

Affiliation

Uehara S; Central Institute for Experimental Animals, Kawasaki, Japan.
Higuchi Y; Central Institute for Experimental Animals, Kawasaki, Japan.
Yoneda N; Central Institute for Experimental Animals, Kawasaki, Japan.
Yamazaki H; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.
Suemizu H; Central Institute for Experimental Animals, Kawasaki, Japan.

Xenobiotica ; 51(10): 1146-1154, 2021 Oct.

Article de En | MEDLINE | ID: mdl-34423713

Sujet(s)
Mots clés

Hu-Liver cells; Lamotrigine; N-glucuronidation; NOG-TKm30 mouse; UGT1A4; humanised-liver mouse

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Glucuronosyltransferase / Anticonvulsivants Limites: Animals Langue: En Journal: Xenobiotica Année: 2021 Type de document: Article Pays d'affiliation: Japon Pays de publication: Royaume-Uni

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