2021 update of the 2012 ICSH Recommendations for identification, diagnostic value, and quantitation of schistocytes: Impact and revisions.
Int J Lab Hematol
; 43(6): 1264-1271, 2021 Dec.
Article
de En
| MEDLINE
| ID: mdl-34431220
ABSTRACT
In 2012, the International Council for Standardization in Hematology (ICSH) published recommendations for the identification, quantitation, and diagnostic value of schistocytes. In the present review, the impact of these recommendations is evaluated. This work is based on citations in peer-reviewed papers published since 2012. The first 2012 ICSH Recommendations have also been revised to incorporate newly published data in the literature and current best laboratory practice. Recommended reference ranges have been proposed for healthy adults and full-term neonates of 1% or less schistocytes. More than 1% of morphologically identified schistocytes on the blood film are considered suspicious for thrombotic microangiopathy. For preterm infants, a normal level of 5% or less is recommended. The fragment red cell count (FRC) generated by some automated hematological analyzers provides a valuable screening tool for the presence of schistocytes. Specifically, the absence of FRCs can be used as a valuable parameter to exclude the presence of schistocytes on the blood film. The validity and usefulness of microscope schistocytes and automated FRCs, respectively, are discussed in the context of the laboratory diagnostic tests used for thrombotic microangiopathies.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Érythrocytes
/
Microangiopathies thrombotiques
Type d'étude:
Diagnostic_studies
/
Guideline
/
Prognostic_studies
Limites:
Adult
/
Humans
/
Newborn
Langue:
En
Journal:
Int J Lab Hematol
Sujet du journal:
HEMATOLOGIA
Année:
2021
Type de document:
Article
Pays d'affiliation:
Italie