Gene Ontology representation for transcription factor functions.
Biochim Biophys Acta Gene Regul Mech
; 1864(11-12): 194752, 2021.
Article
de En
| MEDLINE
| ID: mdl-34461313
ABSTRACT
Transcription plays a central role in defining the identity and functionalities of cells, as well as in their responses to changes in the cellular environment. The Gene Ontology (GO) provides a rigorously defined set of concepts that describe the functions of gene products. A GO annotation is a statement about the function of a particular gene product, represented as an association between a gene product and the biological concept a GO term defines. Critically, each GO annotation is based on traceable scientific evidence. Here, we describe the different GO terms that are associated with proteins involved in transcription and its regulation, focusing on the standard of evidence required to support these associations. This article is intended to help users of GO annotations understand how to interpret the annotations and can contribute to the consistency of GO annotations. We distinguish between three classes of activities involved in transcription or directly regulating it - general transcription factors, DNA-binding transcription factors, and transcription co-regulators.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Facteurs de transcription
/
Régulation de l'expression des gènes
/
Bases de données génétiques
/
Gene Ontology
Langue:
En
Journal:
Biochim Biophys Acta Gene Regul Mech
Année:
2021
Type de document:
Article