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Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression.
Võsa, Urmo; Claringbould, Annique; Westra, Harm-Jan; Bonder, Marc Jan; Deelen, Patrick; Zeng, Biao; Kirsten, Holger; Saha, Ashis; Kreuzhuber, Roman; Yazar, Seyhan; Brugge, Harm; Oelen, Roy; de Vries, Dylan H; van der Wijst, Monique G P; Kasela, Silva; Pervjakova, Natalia; Alves, Isabel; Favé, Marie-Julie; Agbessi, Mawussé; Christiansen, Mark W; Jansen, Rick; Seppälä, Ilkka; Tong, Lin; Teumer, Alexander; Schramm, Katharina; Hemani, Gibran; Verlouw, Joost; Yaghootkar, Hanieh; Sönmez Flitman, Reyhan; Brown, Andrew; Kukushkina, Viktorija; Kalnapenkis, Anette; Rüeger, Sina; Porcu, Eleonora; Kronberg, Jaanika; Kettunen, Johannes; Lee, Bernett; Zhang, Futao; Qi, Ting; Hernandez, Jose Alquicira; Arindrarto, Wibowo; Beutner, Frank; Dmitrieva, Julia; Elansary, Mahmoud; Fairfax, Benjamin P; Georges, Michel; Heijmans, Bastiaan T; Hewitt, Alex W; Kähönen, Mika; Kim, Yungil.
Affiliation
  • Võsa U; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. urmo.vosa@gmail.com.
  • Claringbould A; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia. urmo.vosa@gmail.com.
  • Westra HJ; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. anniqueclaringbould@gmail.com.
  • Bonder MJ; Oncode Institute, Amsterdam, the Netherlands. anniqueclaringbould@gmail.com.
  • Deelen P; Structural & Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany. anniqueclaringbould@gmail.com.
  • Zeng B; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Kirsten H; Oncode Institute, Amsterdam, the Netherlands.
  • Saha A; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Kreuzhuber R; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
  • Yazar S; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Brugge H; Oncode Institute, Amsterdam, the Netherlands.
  • Oelen R; Genomics Coordination Center, University Medical Centre Groningen, Groningen, the Netherlands.
  • de Vries DH; Department of Genetics, University Medical Centre Utrecht, Utrecht, the Netherlands.
  • van der Wijst MGP; School of Biological Sciences, Georgia Tech, Atlanta, GA, USA.
  • Kasela S; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
  • Pervjakova N; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
  • Alves I; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA.
  • Favé MJ; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.
  • Agbessi M; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.
  • Christiansen MW; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
  • Jansen R; Garvan Institute of Medical Research, Garvan-Weizmann Centre for Cellular Genomics, Sydney, New South Wales, Australia.
  • Seppälä I; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Tong L; Oncode Institute, Amsterdam, the Netherlands.
  • Teumer A; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Schramm K; Oncode Institute, Amsterdam, the Netherlands.
  • Hemani G; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Verlouw J; Oncode Institute, Amsterdam, the Netherlands.
  • Yaghootkar H; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Sönmez Flitman R; Oncode Institute, Amsterdam, the Netherlands.
  • Brown A; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
  • Kukushkina V; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
  • Kalnapenkis A; Computational Biology, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Rüeger S; L'institut du thorax, Université de Nantes, CHU Nantes, INSERM, CNRS, Nantes, France.
  • Porcu E; Computational Biology, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Kronberg J; Computational Biology, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Kettunen J; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
  • Lee B; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute and Amsterdam Neuroscience, Amsterdam, the Netherlands.
  • Zhang F; Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
  • Qi T; Department of Public Health Sciences, University of Chicago, Chicago, IL, USA.
  • Hernandez JA; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
  • Arindrarto W; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.
  • Beutner F; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
  • Dmitrieva J; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Elansary M; Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, United Kingdom.
  • Fairfax BP; School of Life Sciences, College of Liberal Arts and Science, University of Westminster, London, United Kingdom.
  • Georges M; Division of Medical Sciences, Department of Health Sciences, Luleå University of Technology, Luleå, Sweden.
  • Heijmans BT; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
  • Hewitt AW; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
  • Kähönen M; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.
  • Kim Y; Population Health and Genomics, University of Dundee, Dundee, United Kingdom.
Nat Genet ; 53(9): 1300-1310, 2021 09.
Article de En | MEDLINE | ID: mdl-34475573
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Protéines du sang / Régulation de l'expression des gènes / Locus de caractère quantitatif Type d'étude: Prognostic_studies Limites: Humans Langue: En Journal: Nat Genet Sujet du journal: GENETICA MEDICA Année: 2021 Type de document: Article Pays d'affiliation: Pays-Bas Pays de publication: États-Unis d'Amérique
Texte intégral
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XML
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Protéines du sang / Régulation de l'expression des gènes / Locus de caractère quantitatif Type d'étude: Prognostic_studies Limites: Humans Langue: En Journal: Nat Genet Sujet du journal: GENETICA MEDICA Année: 2021 Type de document: Article Pays d'affiliation: Pays-Bas Pays de publication: États-Unis d'Amérique