T cells critically depend on pyruvate oxidation.

Schrecker, Christopher; Intlekofer, Andrew M

Schrecker, Christopher; Intlekofer, Andrew M.

Affiliation

Schrecker C; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Intlekofer AM; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: intlekoa@mskcc.org.

Cell Metab ; 33(9): 1719-1720, 2021 09 07.

Article de En | MEDLINE | ID: mdl-34496227

ABSTRACT

ABSTRACT

Supporting the notion that cell lineage is a key determinant of cancer cell metabolism, Jun et al. (2021) identify a selective requirement for pyruvate dehydrogenase (PDH) activity in T cells and T cell leukemia, but not hematopoietic stem cells (HSCs) or myeloid leukemia, in this issue of Cell Metabolism.

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Complexe du pyruvate déshydrogénase / Lymphocytes T Langue: En Journal: Cell Metab Sujet du journal: METABOLISMO Année: 2021 Type de document: Article Pays d'affiliation: États-Unis d'Amérique

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