Cannabinoid receptor 2 is necessary to induce toll-like receptor-mediated microglial activation.
Glia
; 70(1): 71-88, 2022 01.
Article
de En
| MEDLINE
| ID: mdl-34499767
ABSTRACT
The tight regulation of microglia activity is key for precise responses to potential threats, while uncontrolled and exacerbated microglial activity is neurotoxic. Microglial toll-like receptors (TLRs) are indispensable for sensing different types of assaults and triggering an innate immune response. Cannabinoid receptor 2 (CB2) signaling is a key pathway to control microglial homeostasis and activation, and its activation is connected to changes in microglial activity. We aimed to investigate how CB2 signaling impacts TLR-mediated microglial activation. Here, we demonstrate that deletion of CB2 causes a dampened transcriptional response to prototypic TLR ligands in microglia. Loss of CB2 results in distinct microglial gene expression profiles, morphology, and activation. We show that the CB2-mediated attenuation of TLR-induced microglial activation is mainly p38 MAPK-dependent. Taken together, we demonstrate that CB2 expression and signaling are necessary to fine-tune TLR-induced activation programs in microglia.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Microglie
/
Récepteurs de type Toll
Langue:
En
Journal:
Glia
Sujet du journal:
NEUROLOGIA
Année:
2022
Type de document:
Article
Pays d'affiliation:
Allemagne