Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer.

Xu, Congjun; Xiao, Zhanghong; Wang, Jing; Lai, Hualu; Zhang, Tao; Guan, Zilin; Xia, Meng; Chen, Meixu; Ren, Lingling; He, Yuanfeng; Gao, Yuqi; Zhao, Chunshun

Xu, Congjun; Xiao, Zhanghong; Wang, Jing; Lai, Hualu; Zhang, Tao; Guan, Zilin; Xia, Meng; Chen, Meixu; Ren, Lingling; He, Yuanfeng; Gao, Yuqi; Zhao, Chunshun.

Affiliation

Xu C; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Xiao Z; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Wang J; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Lai H; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Zhang T; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Guan Z; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Xia M; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Chen M; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Ren L; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
He Y; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Gao Y; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Zhao C; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.

J Med Chem ; 64(18): 13312-13326, 2021 09 23.

Article de En | MEDLINE | ID: mdl-34506134

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Antienzymes / Ferroptose / Phospholipid hydroperoxide glutathione peroxidase / Acétanilides / Tumeurs / Antinéoplasiques Limites: Animals Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2021 Type de document: Article

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