A Guide to ComBat Harmonization of Imaging Biomarkers in Multicenter Studies.
J Nucl Med
; 63(2): 172-179, 2022 02.
Article
de En
| MEDLINE
| ID: mdl-34531263
ABSTRACT
The impact of PET image acquisition and reconstruction parameters on SUV measurements or radiomic feature values is widely documented. This scanner effect is detrimental to the design and validation of predictive or prognostic models and limits the use of large multicenter cohorts. To reduce the impact of this scanner effect, the ComBat method has been proposed and is now used in various contexts. The purpose of this article is to explain and illustrate the use of ComBat based on practical examples. We also give examples in which the ComBat assumptions are not met and, thus, in which ComBat should not be used.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tomodensitométrie
/
Tomographie par émission de positons
Type d'étude:
Clinical_trials
/
Prognostic_studies
Langue:
En
Journal:
J Nucl Med
Année:
2022
Type de document:
Article