Development and diversification of bipolar interneurons in the mammalian retina.
Dev Biol
; 481: 30-42, 2022 01.
Article
de En
| MEDLINE
| ID: mdl-34534525
ABSTRACT
The bipolar interneurons of the mammalian retina have evolved as a diverse set of cells with distinct subtype characteristics, which reflect specialized contributions to visual circuitry. Fifteen subtypes of bipolar interneurons have been identified in the mouse retina, each with characteristic gene expression, morphology, and light responses. This review provides an overview of the developmental events that underlie the generation of the diverse bipolar cell class, summarizing the current knowledge of genetic programs that establish and maintain bipolar subtype fates, as well as the events that shape the final distribution of bipolar subtypes. With much left to be discovered, bipolar interneurons present an ideal model system for studying the interplay between cell-autonomous and non-cell-autonomous mechanisms that influence neuronal subtype development within the central nervous system.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Rétine
/
Différenciation cellulaire
/
Système nerveux central
/
Régulation de l'expression des gènes au cours du développement
/
Cellules bipolaires rétiniennes
/
Neurogenèse
Type d'étude:
Prognostic_studies
Limites:
Animals
Langue:
En
Journal:
Dev Biol
Année:
2022
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique