Optogenetic Control of Non-Apoptotic Cell Death.
Adv Sci (Weinh)
; 8(13): 2100424, 2021 07.
Article
de En
| MEDLINE
| ID: mdl-34540558
ABSTRACT
Herein, a set of optogenetic tools (designated LiPOP) that enable photoswitchable necroptosis and pyroptosis in live cells with varying kinetics, is introduced. The LiPOP tools allow reconstruction of the key molecular steps involved in these two non-apoptotic cell death pathways by harnessing the power of light. Further, the use of LiPOPs coupled with upconversion nanoparticles or bioluminescence is demonstrated to achieve wireless optogenetic or chemo-optogenetic killing of cancer cells in multiple mouse tumor models. LiPOPs can trigger necroptotic and pyroptotic cell death in cultured prokaryotic or eukaryotic cells and in living animals, and set the stage for studying the role of non-apoptotic cell death pathways during microbial infection and anti-tumor immunity.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Mort cellulaire
/
Optogénétique
Limites:
Animals
/
Humans
Langue:
En
Journal:
Adv Sci (Weinh)
Année:
2021
Type de document:
Article