Periodic charge matching driven immobilization of gentamicin in nanoclays for stable and long-term antibacterial coating.
Dalton Trans
; 50(40): 14216-14222, 2021 Oct 19.
Article
de En
| MEDLINE
| ID: mdl-34550146
ABSTRACT
Matching of charge periodicity between a guest and a host enabled effective immobilization of highly water-soluble antibiotic drug, gentamicin C, in a bentonite clay by cation exchange. X-ray diffraction, infrared spectroscopy and CHNS analysis revealed the immobilization manner of gentamicin C, which was immobilized between bentonite layers via periodic charge-charge interaction with tilted arrangement, as a trication. Both gentamicin alone and a gentamicin/bentonite hybrid were coated onto a polyurethane substrate using water-borne polyurethane binder. The antibiotic character of both films was investigated as prepared or after immersion in phosphate-buffered saline till 5 days against E. coli and B. subtilis bacteria. It was clearly shown that the gentamicin/bentonite hybrid-coated film showed sustained antibacterial efficacy even after exposure to phosphate-buffered saline, while gentamicin only-coated film gradually lost its performance under the same condition.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Bacillus subtilis
/
Gentamicine
/
Argile
/
Escherichia coli
/
Nanoparticules
/
Antibactériens
Langue:
En
Journal:
Dalton Trans
Sujet du journal:
QUIMICA
Année:
2021
Type de document:
Article