Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling.

Schneider, Kai Markus; Candels, Lena Susanna; Hov, Johannes R; Myllys, Maiju; Hassan, Reham; Schneider, Carolin Victoria; Wahlström, Annika; Mohs, Antje; Zühlke, Sebastian; Liao, Lijun; Elfers, Carsten; Kilic, Konrad; Henricsson, Marcus; Molinaro, Antonio; Hatting, Maximilian; Zaza, Ayham; Drasdo, Dirk; Frissen, Mick; Devlin, A Sloan; Gálvez, Eric J C; Strowig, Till; Karlsen, Tom H; Hengstler, Jan G; Marschall, Hanns-Ulrich; Ghallab, Ahmed; Trautwein, Christian

Schneider, Kai Markus; Candels, Lena Susanna; Hov, Johannes R; Myllys, Maiju; Hassan, Reham; Schneider, Carolin Victoria; Wahlström, Annika; Mohs, Antje; Zühlke, Sebastian; Liao, Lijun; Elfers, Carsten; Kilic, Konrad; Henricsson, Marcus; Molinaro, Antonio; Hatting, Maximilian; Zaza, Ayham; Drasdo, Dirk; Frissen, Mick; Devlin, A Sloan; Gálvez, Eric J C; Strowig, Till; Karlsen, Tom H; Hengstler, Jan G; Marschall, Hanns-Ulrich; Ghallab, Ahmed; Trautwein, Christian.

Affiliation

Schneider KM; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany.
Candels LS; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Hov JR; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany.
Myllys M; Norwegian PSC Research Center, Section of Gastroenterology and Research Institute of Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital and University of Oslo, Oslo, Norway.
Hassan R; Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund, Dortmund, Germany.
Schneider CV; Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund, Dortmund, Germany.
Wahlström A; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt.
Mohs A; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany.
Zühlke S; Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Liao L; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany.
Elfers C; Center for Mass Spectrometry (CMS), Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.
Kilic K; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany.
Henricsson M; Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University, Shanghai, China.
Molinaro A; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany.
Hatting M; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany.
Zaza A; Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Drasdo D; Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Frissen M; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany.
Devlin AS; Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund, Dortmund, Germany.
Gálvez EJC; Institute National de Recherche en Informatique et en Automatique (INRIA), Le Chesnay, France.
Strowig T; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany.
Karlsen TH; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Hengstler JG; Helmholtz Centre for Infection Research, Braunschweig, Germany and Hannover Medical School, Hannover, Germany.
Marschall HU; Helmholtz Centre for Infection Research, Braunschweig, Germany and Hannover Medical School, Hannover, Germany.
Ghallab A; Norwegian PSC Research Center, Section of Gastroenterology and Research Institute of Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital and University of Oslo, Oslo, Norway.
Trautwein C; Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund, Dortmund, Germany.

Nat Metab ; 3(9): 1228-1241, 2021 09.

Article de En | MEDLINE | ID: mdl-34552267

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Acides et sels biliaires / Transduction du signal / Cholestase / Récepteurs cytoplasmiques et nucléaires / Microbiome gastro-intestinal Type d'étude: Prognostic_studies Limites: Animals / Humans Langue: En Journal: Nat Metab Année: 2021 Type de document: Article Pays d'affiliation: Allemagne

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