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Health-Related Quality of Life of Patients with Recurrent or Metastatic Cutaneous Squamous Cell Carcinoma Treated with Pembrolizumab in KEYNOTE-629.
Hughes, Brett G M; Mendoza, Rene Gonzalez; Basset-Seguin, Nicole; Vornicova, Olga; Schachter, Jacob; Joshi, Abhishek; Meyer, Nicolas; Grange, Florent; Piulats, Josep M; Bauman, Jessica R; Chirovsky, Diana; Zhang, Pingye; Gumuscu, Burak; Swaby, Ramona F; Grob, Jean-Jacques.
Affiliation
  • Hughes BGM; Royal Brisbane and Women's Hospital, Herston, QLD, Australia. brett.hughes@health.qld.gov.au.
  • Mendoza RG; University of Queensland, Brisbane, QLD, Australia. brett.hughes@health.qld.gov.au.
  • Basset-Seguin N; Centro Estatal de Cancerológia de Chihuahua, Chihuahua, Mexico.
  • Vornicova O; Hôpital Saint-Louis, Paris, France.
  • Schachter J; Rambam Health Care Campus, Haifa, Israel.
  • Joshi A; The Chaim Sheba Medical Center at Tel HaShomer, Ramat Gan, Israel.
  • Meyer N; Townsville University Hospital, Townsville, QLD, Australia.
  • Grange F; Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France.
  • Piulats JM; Centre Hospitalier Universitaire de Reims-Hoˆpital Robert Debre, Reims, France.
  • Bauman JR; Centre Hospitalier Universitaire de Reims Hôpital Robert Debré, Valence, France.
  • Chirovsky D; Hospital Duran i Reinals ICO de Hospitalet, Barcelona, Spain.
  • Zhang P; Fox Chase Cancer Center, Philadelphia, PA, USA.
  • Gumuscu B; Merck & Co., Inc, Kenilworth, NJ, USA.
  • Swaby RF; Merck & Co., Inc, Kenilworth, NJ, USA.
  • Grob JJ; Merck & Co., Inc, Kenilworth, NJ, USA.
Dermatol Ther (Heidelb) ; 11(5): 1777-1790, 2021 Oct.
Article de En | MEDLINE | ID: mdl-34558040
Cutaneous squamous cell carcinoma (cSCC) is the second most common type of non-melanoma skin cancer. cSCC is usually caused by cumulative exposure to sunlight and often occurs in exposed parts of the body such as the head and neck. cSCC is most often seen in older people. If cSCC is detected early, it can be removed by surgery; however, if left untreated, the cancer can spread throughout the body and cause death. The disease itself and its treatment can be painful, cause scarring, or change the patient's physical appearance. Hence, people with cSCC often have poor quality of life. It is therefore important to develop new drugs to help patients with cSCC live longer without worsening their quality of life. The phase 2 KEYNOTE-629 study investigated how well the drug pembrolizumab treated cSCC and whether it was safe. KEYNOTE-629 included patients who were mostly older and had advanced cSCC. The results showed that pembrolizumab was effective and safe. Here, we investigated how pembrolizumab affected the quality of life of these patients. To do this, we asked patients to answer questionnaires on important aspects of their experience, such as their general health status, physical functioning, emotional wellbeing, and symptoms. We found that patients who were treated with pembrolizumab had stable quality of life during treatment. Furthermore, patients whose cancer responded well to pembrolizumab were more likely to have an improved quality of life. These results support the use of pembrolizumab in patients with advanced cSCC.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Type d'étude: Prognostic_studies Aspects: Patient_preference Langue: En Journal: Dermatol Ther (Heidelb) Année: 2021 Type de document: Article Pays d'affiliation: Australie Pays de publication: Suisse

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Type d'étude: Prognostic_studies Aspects: Patient_preference Langue: En Journal: Dermatol Ther (Heidelb) Année: 2021 Type de document: Article Pays d'affiliation: Australie Pays de publication: Suisse