A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models.

Yu, Xufen; Li, Dongxu; Kottur, Jithesh; Shen, Yudao; Kim, Huen Suk; Park, Kwang-Su; Tsai, Yi-Hsuan; Gong, Weida; Wang, Jun; Suzuki, Kyogo; Parker, Joel; Herring, Laura; Kaniskan, H Ümit; Cai, Ling; Jain, Rinku; Liu, Jing; Aggarwal, Aneel K; Wang, Gang Greg; Jin, Jian

Yu, Xufen; Li, Dongxu; Kottur, Jithesh; Shen, Yudao; Kim, Huen Suk; Park, Kwang-Su; Tsai, Yi-Hsuan; Gong, Weida; Wang, Jun; Suzuki, Kyogo; Parker, Joel; Herring, Laura; Kaniskan, H Ümit; Cai, Ling; Jain, Rinku; Liu, Jing; Aggarwal, Aneel K; Wang, Gang Greg; Jin, Jian.

Affiliation

Yu X; Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Li D; Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Kottur J; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Shen Y; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Kim HS; Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Park KS; Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Tsai YH; Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Gong W; Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Wang J; Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Suzuki K; Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Parker J; Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Herring L; Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Kaniskan HÜ; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Cai L; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Jain R; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Liu J; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Aggarwal AK; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Wang GG; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Jin J; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Sci Transl Med ; 13(613): eabj1578, 2021 Sep 29.

Article de En | MEDLINE | ID: mdl-34586829

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Leucémie aigüe myéloïde / Protéine de la leucémie myéloïde-lymphoïde Limites: Animals / Humans Langue: En Journal: Sci Transl Med Sujet du journal: CIENCIA / MEDICINA Année: 2021 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique

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