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CP-25 exerts therapeutic effects in mice with dextran sodium sulfate-induced colitis by inhibiting GRK2 translocation to downregulate the TLR4-NF-κB-NLRP3 inflammasome signaling pathway in macrophages.
Li, Ying; Jiang, Meng-Ya; Chen, Jing-Yu; Xu, Zhou-Wei; Zhang, Jia-Wei; Li, Tao; Zhang, Ling-Ling; Wei, Wei.
Affiliation
  • Li Y; Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-inflammatory and Immune Medicines, Hefei, China.
  • Jiang MY; Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-inflammatory and Immune Medicines, Hefei, China.
  • Chen JY; Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-inflammatory and Immune Medicines, Hefei, China.
  • Xu ZW; Department of Emergency Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
  • Zhang JW; Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-inflammatory and Immune Medicines, Hefei, China.
  • Li T; Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
  • Zhang LL; Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-inflammatory and Immune Medicines, Hefei, China.
  • Wei W; Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
IUBMB Life ; 73(12): 1406-1422, 2021 12.
Article de En | MEDLINE | ID: mdl-34590407
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Colite / Inflammasomes Type d'étude: Prognostic_studies Limites: Animals / Humans Langue: En Journal: IUBMB Life Sujet du journal: BIOLOGIA MOLECULAR / BIOQUIMICA Année: 2021 Type de document: Article Pays d'affiliation: Chine
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Colite / Inflammasomes Type d'étude: Prognostic_studies Limites: Animals / Humans Langue: En Journal: IUBMB Life Sujet du journal: BIOLOGIA MOLECULAR / BIOQUIMICA Année: 2021 Type de document: Article Pays d'affiliation: Chine