Type I Diabetes Mellitus Increases the Cardiovascular Complications of Influenza Virus Infection.
Front Cell Infect Microbiol
; 11: 714440, 2021.
Article
de En
| MEDLINE
| ID: mdl-34595130
ABSTRACT
People with diabetes mellitus are susceptible to both cardiovascular disease and severe influenza A virus infection. We hypothesized that diabetes also increases risks of influenza-associated cardiac complications. A murine type 1 (streptozotocin-induced) diabetes model was employed to investigate influenza-induced cardiac distress. Lung histopathology and viral titres revealed no difference in respiratory severity between infected control and diabetic mice. However, compared with infected control mice, infected diabetic mice had increased serum cardiac troponin I and creatine-kinase MB, left ventricular structural changes and right ventricular functional alterations, providing the first experimental evidence of type I diabetes increasing risks of influenza-induced cardiovascular complications.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Virus de la grippe A
/
Infections à Orthomyxoviridae
/
Diabète expérimental
/
Diabète de type 1
/
Grippe humaine
Limites:
Animals
/
Humans
Langue:
En
Journal:
Front Cell Infect Microbiol
Année:
2021
Type de document:
Article
Pays d'affiliation:
Australie