Molecular Link between Circadian Rhythmicity and Mood Disorders.
Curr Med Chem
; 29(36): 5692-5709, 2022.
Article
de En
| MEDLINE
| ID: mdl-34620057
ABSTRACT
BACKGROUND:
The internal clock is driven by circadian genes [e.g., Clock, Bmal1, Per1-3, Cry1-2], hormones [e.g., melatonin, cortisol], as well as zeitgeber ['synchronisers']. Chronic disturbances in the circadian rhythm inObjectives:
The aim of this review is to summarise the current knowledge and literature regarding circadian rhythms in the context of mood disorders, focussing on the role of circadian genes, hormones, and neurotransmitters.METHODS:
The review presents the current knowledge and literature regarding circadian rhythms in mood disorders using the Pubmed database. Articles with a focus on circadian rhythms and mood disorders [n=123], particularly from 1973 to 2020, were included.RESULTS:
The article suggests a molecular link between disruptions in the circadian rhythm and mood disorders. Circadian disturbances, caused by the dysregulation of circadian genes, hormones, and neurotransmitters, often result in a clinical picture resembling depression.CONCLUSION:
The article suggests a molecular link between disruptions in the circadian rhythm and mood disorders. Circadian disturbances, caused by the dysregulation of circadian genes, hormones, and neurotransmitters, often result in a clinical picture resembling depression.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Rythme circadien
/
Mélatonine
Limites:
Humans
Langue:
En
Journal:
Curr Med Chem
Sujet du journal:
QUIMICA
Année:
2022
Type de document:
Article
Pays d'affiliation:
Allemagne