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PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory.
Cannons, Jennifer L; Villarino, Alejandro V; Kapnick, Senta M; Preite, Silvia; Shih, Han-Yu; Gomez-Rodriguez, Julio; Kaul, Zenia; Shibata, Hirofumi; Reilley, Julie M; Huang, Bonnie; Handon, Robin; McBain, Ian T; Gossa, Selamawit; Wu, Tuoqi; Su, Helen C; McGavern, Dorian B; O'Shea, John J; McGuire, Peter J; Uzel, Gulbu; Schwartzberg, Pamela L.
Affiliation
  • Cannons JL; National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA; National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA. Electronic address: jcannons@mail.nih.gov.
  • Villarino AV; National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA; Department of Microbiology & Immunology and Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.
  • Kapnick SM; National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA; Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
  • Preite S; National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA; National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
  • Shih HY; National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA; National Eye Institute, NIH, Bethesda, MD 20892, USA.
  • Gomez-Rodriguez J; National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA; National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA; TCR2 Therapeutics, Cambridge, MA 02142, USA.
  • Kaul Z; National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  • Shibata H; National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  • Reilley JM; National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA; National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
  • Huang B; National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA; National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
  • Handon R; National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
  • McBain IT; National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  • Gossa S; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA.
  • Wu T; National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA; National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA; University of Colorado, Department of Immunology, Denver, CO 80204, USA; Department of Immunology and Harold C. Simmons Comprehensive Cancer Ce
  • Su HC; National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  • McGavern DB; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA.
  • O'Shea JJ; National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA.
  • McGuire PJ; National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
  • Uzel G; National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  • Schwartzberg PL; National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA; National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA. Electronic address: pams@nih.gov.
Cell Rep ; 37(2): 109804, 2021 10 12.
Article de En | MEDLINE | ID: mdl-34644563
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Transcription génétique / Maladies virales / Chromatine / Lymphocytes T CD8/ / Assemblage et désassemblage de la chromatine / Phosphatidylinositol 3-kinases de classe I / Maladies d'immunodéficience primaire / Mémoire immunologique Type d'étude: Health_economic_evaluation / Observational_studies / Prognostic_studies / Risk_factors_studies Limites: Adolescent / Adult / Animals / Child / Female / Humans / Male Langue: En Journal: Cell Rep Année: 2021 Type de document: Article
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Transcription génétique / Maladies virales / Chromatine / Lymphocytes T CD8/ / Assemblage et désassemblage de la chromatine / Phosphatidylinositol 3-kinases de classe I / Maladies d'immunodéficience primaire / Mémoire immunologique Type d'étude: Health_economic_evaluation / Observational_studies / Prognostic_studies / Risk_factors_studies Limites: Adolescent / Adult / Animals / Child / Female / Humans / Male Langue: En Journal: Cell Rep Année: 2021 Type de document: Article