A phase 2 biomarker-driven study of ruxolitinib demonstrates effectiveness of JAK/STAT targeting in T-cell lymphomas.

Moskowitz, Alison J; Ghione, Paola; Jacobsen, Eric; Ruan, Jia; Schatz, Jonathan H; Noor, Sarah; Myskowski, Patricia; Vardhana, Santosha; Ganesan, Nivetha; Hancock, Helen; Davey, Theresa; Perez, Leslie; Ryu, Sunyoung; Santarosa, Alayna; Dowd, Jack; Obadi, Obadi; Pomerantz, Lauren; Yi, Nancy; Sohail, Samia; Galasso, Natasha; Neuman, Rachel; Liotta, Brielle; Blouin, William; Baik, Jeeyeon; Geyer, Mark B; Noy, Ariela; Straus, David; Kumar, Priyadarshini; Dogan, Ahmet; Hollmann, Travis; Drill, Esther; Rademaker, Jurgen; Schoder, Heiko; Inghirami, Giorgio; Weinstock, David M; Horwitz, Steven M

Moskowitz, Alison J; Ghione, Paola; Jacobsen, Eric; Ruan, Jia; Schatz, Jonathan H; Noor, Sarah; Myskowski, Patricia; Vardhana, Santosha; Ganesan, Nivetha; Hancock, Helen; Davey, Theresa; Perez, Leslie; Ryu, Sunyoung; Santarosa, Alayna; Dowd, Jack; Obadi, Obadi; Pomerantz, Lauren; Yi, Nancy; Sohail, Samia; Galasso, Natasha; Neuman, Rachel; Liotta, Brielle; Blouin, William; Baik, Jeeyeon; Geyer, Mark B; Noy, Ariela; Straus, David; Kumar, Priyadarshini; Dogan, Ahmet; Hollmann, Travis; Drill, Esther; Rademaker, Jurgen; Schoder, Heiko; Inghirami, Giorgio; Weinstock, David M; Horwitz, Steven M.

Affiliation

Moskowitz AJ; Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, NY.
Ghione P; Department of Medicine, Weill Cornell Medical Center, New York, NY.
Jacobsen E; Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, NY.
Ruan J; Lymphoma Service, Roswell Park Comprehensive Cancer Center, Buffalo, NY.
Schatz JH; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
Noor S; Lymphoma Service, Weill Cornell Medical Center, New York, NY.
Myskowski P; Division of Hematology, Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL; and.
Vardhana S; Dermatology Service.
Ganesan N; Dermatology Service.
Hancock H; Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, NY.
Davey T; Department of Medicine, Weill Cornell Medical Center, New York, NY.
Perez L; Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, NY.
Ryu S; Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, NY.
Santarosa A; Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, NY.
Dowd J; Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, NY.
Obadi O; Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, NY.
Pomerantz L; Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, NY.
Yi N; Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, NY.
Sohail S; Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, NY.
Galasso N; Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, NY.
Neuman R; Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, NY.
Liotta B; Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, NY.
Blouin W; Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, NY.
Baik J; Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, NY.
Geyer MB; Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, NY.
Noy A; Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, NY.
Straus D; Department of Pathology.
Kumar P; Leukemia Service.
Dogan A; Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, NY.
Hollmann T; Department of Medicine, Weill Cornell Medical Center, New York, NY.
Drill E; Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, NY.
Rademaker J; Department of Medicine, Weill Cornell Medical Center, New York, NY.
Schoder H; Department of Pathology.
Inghirami G; Department of Pathology.
Weinstock DM; Department of Pathology.
Horwitz SM; Department of Biostatistics.

Blood ; 138(26): 2828-2837, 2021 12 30.

Article de En | MEDLINE | ID: mdl-34653242

Sujet(s)

Texte intégral

Ajouter à My VHL

Imprimer

XML

PubMed Links

Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pyrazoles / Pyrimidines / Lymphome T périphérique / Inhibiteurs de protéines kinases / Facteurs de transcription STAT / Janus kinases / Nitriles Type d'étude: Clinical_trials Limites: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Langue: En Journal: Blood Année: 2021 Type de document: Article Pays de publication: États-Unis d'Amérique

Texte intégral

Ajouter à My VHL

Imprimer

XML

PubMed Links

Recherche sur Google