Bisphenol A single and repeated treatment increases HDAC2, leading to cholinergic neurotransmission dysfunction and SN56 cholinergic apoptotic cell death through AChE variants overexpression and NGF/TrkA/P75<sup>NTR</sup> signaling disruption.

Moyano, Paula; Flores, Andrea; García, Jimena; García, José Manuel; Anadon, María José; Frejo, María Teresa; Sola, Emma; Pelayo, Adela; Del Pino, Javier

Bisphenol A single and repeated treatment increases HDAC2, leading to cholinergic neurotransmission dysfunction and SN56 cholinergic apoptotic cell death through AChE variants overexpression and NGF/TrkA/P75^NTR signaling disruption.

Moyano, Paula; Flores, Andrea; García, Jimena; García, José Manuel; Anadon, María José; Frejo, María Teresa; Sola, Emma; Pelayo, Adela; Del Pino, Javier.

Affiliation

Moyano P; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Flores A; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
García J; Department of Pharmacolgy, Health Sciences School, Alfonso X University, 28691, Madrid, Spain.
García JM; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: josgar27@ucm.es.
Anadon MJ; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
Frejo MT; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Sola E; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
Pelayo A; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
Del Pino J; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: jdelpino@pdi.ucm.es.

Food Chem Toxicol ; 157: 112614, 2021 Nov.

Article de En | MEDLINE | ID: mdl-34655688

Sujet(s)
Mots clés

AChE; Bisphenol A; ChAT; HDAC2; NGF; P75(NTR); SN56 basal forebrain cholinergic neurons; TrkA

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Phénols / Composés benzhydryliques / Transduction du signal / Récepteurs facteur croissance nerf / Apoptose / Transmission synaptique / Récepteur trkA / Facteur de croissance nerveuse / Histone Deacetylase 2 / Neurones cholinergiques Limites: Animals Langue: En Journal: Food Chem Toxicol Année: 2021 Type de document: Article Pays d'affiliation: Espagne

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