Delicate balance among thermal stability, binding affinity, and conformational space explored by single-domain V<sub>H</sub>H antibodies.

Ikeuchi, Emina; Kuroda, Daisuke; Nakakido, Makoto; Murakami, Akikazu; Tsumoto, Kouhei

Delicate balance among thermal stability, binding affinity, and conformational space explored by single-domain V_HH antibodies.

Ikeuchi, Emina; Kuroda, Daisuke; Nakakido, Makoto; Murakami, Akikazu; Tsumoto, Kouhei.

Affiliation

Ikeuchi E; Department of Bioengineering, School of Engineering, The University of Tokyo, Tokyo, 108-8639, Japan.
Kuroda D; Panasonic Corporation Technology Division, Kyoto, 619-0237, Japan.
Nakakido M; Department of Bioengineering, School of Engineering, The University of Tokyo, Tokyo, 108-8639, Japan.
Murakami A; Medical Device Development and Regulation Research Center, School of Engineering, The University of Tokyo, Tokyo, 108-8639, Japan.
Tsumoto K; Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Tokyo, Japan.

Sci Rep ; 11(1): 20624, 2021 10 18.

Article de En | MEDLINE | ID: mdl-34663870

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Anticorps à chaîne unique / Anticorps Limites: Animals / Humans Langue: En Journal: Sci Rep Année: 2021 Type de document: Article Pays d'affiliation: Japon Pays de publication: Royaume-Uni

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