Method to Create Multiple Primary Malignant Neoplasms with Stimulation of Tumor Growth under Conditions of Primary Immunodeficiency in Experiment.
Bull Exp Biol Med
; 171(6): 770-773, 2021 Oct.
Article
de En
| MEDLINE
| ID: mdl-34705181
ABSTRACT
The experimental model of synchronous multiple primary malignant tumors (MPMT) was created. B16/F10 melanoma (0.5 ml of suspension diluted 120 in saline) and sarcoma 45 (0.5 million tumor cells in 0.5 ml saline) were simultaneously subcutaneously inoculated to male BALB/c nude mice. In the model of synchronous MPMT, the tumors appeared faster by 2.4 times and had greater volumes melanoma by 2.2 times and sarcoma by 3.2 times; melanoma metastasized into sarcoma in 71.4% cases; the survival of mice with MPMT was lower. The altered dynamics of malignant growth in the MPMT model is based on the mutual influence of tumors, which results in the exchange of "structural information".
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs cutanées
/
Mélanome expérimental
/
Maladies d'immunodéficience primaire
/
Tumeurs du poumon
/
Transplantation tumorale
/
Tumeurs primitives multiples
Limites:
Animals
Langue:
En
Journal:
Bull Exp Biol Med
Année:
2021
Type de document:
Article
Pays d'affiliation:
Russie