Role of purinergic system and vitamin D in the anti-cancer immune response.
Life Sci
; 287: 120110, 2021 Dec 15.
Article
de En
| MEDLINE
| ID: mdl-34743945
ABSTRACT
For several years, scientists have recognized that vitamin D plays an important role in mineral and bone homeostasis. It was mostly used to treat osteoporosis and rickets in the past decades. Vitamin D has also been discovered to be modulator of the immune system and may play a role in a variety of diseases, including autoimmune diseases, in recent years. Vitamin D interaction with the vitamin D receptor (VDR), which has transcriptional imparts and is displayed on a variety of cell types, including those of the immune system, appears to be accountable for the immune-modulating effects. The action of tumor cells and vitamin D were the first to be investigated, but the spotlight is now on immunologic and purinergic systems. We conducted a systematic search in Pub Med as well as Google scholar for studies written in English. Vitamin D, cancer, purinergic signaling, and immune response were among the search words. Vitamin D has the potential to be a useful coadjuvant in cancer therapy and the purinergic system may be a potential treatment target to cancer therapy, according to our findings.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Vitamine D
/
Récepteurs purinergiques
/
Récepteur calcitriol
/
Immunité cellulaire
/
Tumeurs
/
Antinéoplasiques
Limites:
Humans
Langue:
En
Journal:
Life Sci
Année:
2021
Type de document:
Article