Nitrofurantoin-induced agranulocytosis.
BMJ Case Rep
; 14(11)2021 Nov 11.
Article
de En
| MEDLINE
| ID: mdl-34764131
ABSTRACT
Idiosyncratic drug-induced agranulocytosis is a rare life-threatening adverse reaction characterised by an absolute neutrophil count <500 cells/µL of blood. Nitrofurantoin has been associated with haematological adverse events, but few agranulocytosis cases worldwide have been reported. We present a case of a 68-year-old woman who presented with fever and agranulocytosis following treatment with nitrofurantoin. Extensive workup for agranulocytosis, including a bone marrow aspirate, was unremarkable. Treatment with nitrofurantoin was discontinued, which led to a complete recovery of the complete blood count. This case stresses the importance of monitoring treatments, given that widely used drugs are not free from severe adverse reactions.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Neutropénie
/
Nitrofurantoïne
Limites:
Aged
/
Female
/
Humans
Langue:
En
Journal:
BMJ Case Rep
Année:
2021
Type de document:
Article
Pays d'affiliation:
Portugal