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MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function.
Sugiura, Ayaka; Andrejeva, Gabriela; Voss, Kelsey; Heintzman, Darren R; Xu, Xincheng; Madden, Matthew Z; Ye, Xiang; Beier, Katherine L; Chowdhury, Nowrin U; Wolf, Melissa M; Young, Arissa C; Greenwood, Dalton L; Sewell, Allison E; Shahi, Shailesh K; Freedman, Samantha N; Cameron, Alanna M; Foerch, Patrik; Bourne, Tim; Garcia-Canaveras, Juan C; Karijolich, John; Newcomb, Dawn C; Mangalam, Ashutosh K; Rabinowitz, Joshua D; Rathmell, Jeffrey C.
Affiliation
  • Sugiura A; Vanderbilt Center for Immunobiology, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Andrejeva G; Vanderbilt Center for Immunobiology, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Voss K; Vanderbilt Center for Immunobiology, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Heintzman DR; Vanderbilt Center for Immunobiology, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Xu X; Department of Chemistry, Ludwig Cancer Research Institute Princeton Branch, Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
  • Madden MZ; Vanderbilt Center for Immunobiology, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Ye X; Vanderbilt Center for Immunobiology, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Beier KL; Vanderbilt Center for Immunobiology, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Chowdhury NU; Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Wolf MM; Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Young AC; Vanderbilt Center for Immunobiology, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Greenwood DL; Vanderbilt Center for Immunobiology, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Sewell AE; Vanderbilt Center for Immunobiology, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Shahi SK; Department of Pathology, University of Iowa, Iowa City, IA 52242, USA.
  • Freedman SN; Department of Pathology, University of Iowa, Iowa City, IA 52242, USA.
  • Cameron AM; Sitryx Therapeutics Limited, Magdalen Centre, Oxford Science Park, Oxford, UK.
  • Foerch P; Sitryx Therapeutics Limited, Magdalen Centre, Oxford Science Park, Oxford, UK.
  • Bourne T; Sitryx Therapeutics Limited, Magdalen Centre, Oxford Science Park, Oxford, UK.
  • Garcia-Canaveras JC; Department of Chemistry, Ludwig Cancer Research Institute Princeton Branch, Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
  • Karijolich J; Vanderbilt Center for Immunobiology, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Newcomb DC; Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Mangalam AK; Department of Pathology, University of Iowa, Iowa City, IA 52242, USA.
  • Rabinowitz JD; Department of Chemistry, Ludwig Cancer Research Institute Princeton Branch, Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
  • Rathmell JC; Vanderbilt Center for Immunobiology, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: jeff.rathmell@vumc.org.
Immunity ; 55(1): 65-81.e9, 2022 01 11.
Article de En | MEDLINE | ID: mdl-34767747
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Purines / Lymphocytes T régulateurs / Cellules Th17 / Complexe-1 cible mécanistique de la rapamycine / Inflammation / Methylenetetrahydrofolate Dehydrogenase (NADP) Type d'étude: Prognostic_studies Limites: Animals / Humans Langue: En Journal: Immunity Sujet du journal: ALERGIA E IMUNOLOGIA Année: 2022 Type de document: Article Pays d'affiliation: États-Unis d'Amérique
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Purines / Lymphocytes T régulateurs / Cellules Th17 / Complexe-1 cible mécanistique de la rapamycine / Inflammation / Methylenetetrahydrofolate Dehydrogenase (NADP) Type d'étude: Prognostic_studies Limites: Animals / Humans Langue: En Journal: Immunity Sujet du journal: ALERGIA E IMUNOLOGIA Année: 2022 Type de document: Article Pays d'affiliation: États-Unis d'Amérique