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AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models.
Varadi, Mihaly; Anyango, Stephen; Deshpande, Mandar; Nair, Sreenath; Natassia, Cindy; Yordanova, Galabina; Yuan, David; Stroe, Oana; Wood, Gemma; Laydon, Agata; Zídek, Augustin; Green, Tim; Tunyasuvunakool, Kathryn; Petersen, Stig; Jumper, John; Clancy, Ellen; Green, Richard; Vora, Ankur; Lutfi, Mira; Figurnov, Michael; Cowie, Andrew; Hobbs, Nicole; Kohli, Pushmeet; Kleywegt, Gerard; Birney, Ewan; Hassabis, Demis; Velankar, Sameer.
Affiliation
  • Varadi M; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
  • Anyango S; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
  • Deshpande M; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
  • Nair S; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
  • Natassia C; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
  • Yordanova G; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
  • Yuan D; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
  • Stroe O; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
  • Wood G; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
  • Laydon A; DeepMind, London, UK.
  • Zídek A; DeepMind, London, UK.
  • Green T; DeepMind, London, UK.
  • Tunyasuvunakool K; DeepMind, London, UK.
  • Petersen S; DeepMind, London, UK.
  • Jumper J; DeepMind, London, UK.
  • Clancy E; DeepMind, London, UK.
  • Green R; DeepMind, London, UK.
  • Vora A; DeepMind, London, UK.
  • Lutfi M; DeepMind, London, UK.
  • Figurnov M; DeepMind, London, UK.
  • Cowie A; DeepMind, London, UK.
  • Hobbs N; DeepMind, London, UK.
  • Kohli P; DeepMind, London, UK.
  • Kleywegt G; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
  • Birney E; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
  • Hassabis D; DeepMind, London, UK.
  • Velankar S; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
Nucleic Acids Res ; 50(D1): D439-D444, 2022 01 07.
Article de En | MEDLINE | ID: mdl-34791371
ABSTRACT
The AlphaFold Protein Structure Database (AlphaFold DB, https//alphafold.ebi.ac.uk) is an openly accessible, extensive database of high-accuracy protein-structure predictions. Powered by AlphaFold v2.0 of DeepMind, it has enabled an unprecedented expansion of the structural coverage of the known protein-sequence space. AlphaFold DB provides programmatic access to and interactive visualization of predicted atomic coordinates, per-residue and pairwise model-confidence estimates and predicted aligned errors. The initial release of AlphaFold DB contains over 360,000 predicted structures across 21 model-organism proteomes, which will soon be expanded to cover most of the (over 100 million) representative sequences from the UniRef90 data set.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Logiciel / Protéines / Pliage des protéines / Bases de données de protéines Type d'étude: Prognostic_studies Limites: Animals / Humans Langue: En Journal: Nucleic Acids Res Année: 2022 Type de document: Article Pays d'affiliation: Royaume-Uni
Texte intégral
Ajouter à My VHL
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XML
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Logiciel / Protéines / Pliage des protéines / Bases de données de protéines Type d'étude: Prognostic_studies Limites: Animals / Humans Langue: En Journal: Nucleic Acids Res Année: 2022 Type de document: Article Pays d'affiliation: Royaume-Uni